发明名称 |
Stable liquid parenteral parecoxib formulation |
摘要 |
A parenterally deliverable pharmaceutical composition comprises a water soluble parecoxib salt, in dissolved and/or solubilized form in a solvent liquid that comprises water and one or more nonaqueous solubilizer(s). Valdecoxib formed by conversion of parecoxib is solubilized by the nonaqueous solubilizer(s), which are substantially inert with respect to such conversion. The composition has parecoxib salt stabilizing means for inhibiting precipitation of parecoxib free acid. The composition is storage stable and is suitable for parenteral administration to treat a COX-2 mediated condition or disorder.
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申请公布号 |
US2004127537(A1) |
申请公布日期 |
2004.07.01 |
申请号 |
US20030464015 |
申请日期 |
2003.06.18 |
申请人 |
GOKARN YATIN R.;SCHARTMAN RICHARD |
发明人 |
GOKARN YATIN R.;SCHARTMAN RICHARD |
分类号 |
A61K9/08;A61K9/00;A61K31/42;A61K47/04;A61K47/10;A61K47/16;A61K47/18;A61K47/22;A61K47/34;A61P1/02;A61P1/04;A61P1/16;A61P3/10;A61P7/02;A61P7/06;A61P9/00;A61P9/04;A61P9/10;A61P9/14;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P15/00;A61P15/06;A61P17/00;A61P17/02;A61P17/06;A61P17/10;A61P17/16;A61P19/02;A61P19/06;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/04;A61P25/06;A61P25/28;A61P27/02;A61P27/06;A61P27/12;A61P29/00;A61P31/12;A61P35/04;A61P37/06;A61P41/00;A61P43/00;(IPC1-7):A61K31/415 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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