Chimeric ebola envelope proteins and uses therefore are described. The chimeric envelope proteins are useful for packaging viral vectors and targeting these vectors in vivo, to lung cells following intratracheal delivery or for delivery of molecules, ex vivo, to macrophages and dendritic cells. In another aspect, also provided herein are immunogenic compositions which contain ebola envelope proteins and uses thereof.
申请公布号
WO03092582(A3)
申请公布日期
2004.07.01
申请号
WO2003US11494
申请日期
2003.04.28
申请人
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;WILSON, JAMES, M.;MEDINA, MARIA, FE, C.;KOBINGER, GARY
发明人
WILSON, JAMES, M.;MEDINA, MARIA, FE, C.;KOBINGER, GARY