发明名称 |
RECOMBINANT VIRAL-BASED MALARIA VACCINES |
摘要 |
<p>The present invention relates to novel vaccines against malaria infections, based on recombinant viral vectors, such as alphaviruses, adenoviruses or vaccinia viruses. The recombinant viral-based vaccines can be applied for immunization against different Plasmodium infections, such as infections by P.falciparum or P.yoelii. Novel codon-optimized circumsporozoite (CS) genes are disclosed. Preferably, replication-defective adenoviruses are used, derived of serotypes that encounter low titers of neutralizing antibodies. The invention therefore also relates to the use of different adenoviral serotypes that are administered to elicit a strong immune response, either in single vaccination setups, or in prime-boost set-ups in which compositions based on different serotypes can be applied.</p> |
申请公布号 |
WO2004055187(A1) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003EP51019 |
申请日期 |
2003.12.16 |
申请人 |
CRUCELL HOLLAND B.V.;PAU, MARIA GRAZIA;HOLTERMAN, LENNART;KASPERS, JORN;STEGMANN, ANTONIUS, JOHANNES, HENDRIKUS |
发明人 |
PAU, MARIA GRAZIA;HOLTERMAN, LENNART;KASPERS, JORN;STEGMANN, ANTONIUS, JOHANNES, HENDRIKUS |
分类号 |
A01N65/00;A61K39/015;C07K14/445;C12N15/30;C12N15/861;(IPC1-7):C12N15/30 |
主分类号 |
A01N65/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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