发明名称 |
ANKTM1, A COLD-ACTIVATED TRP-LIKE CHANNEL EXPRESSED IN NOCICEPTIVE NEURONS |
摘要 |
<p>The methods and compositions of the invention are based on a method for measuring nociceptive responses in vertebrates, including humans and other mammals utilizing a newly discovered thermoreceptor belonging to the Transient Receptor Potential (TRP) family of non-selective cation channels that participates in thermosensation and pain. This receptor, designated ANKTMI, is associated with nociceptive pain, such as hyperalgesia. Accordingly, the invention provides isolated polypeptides and polynucleotides associated with nociception as well as methods for identifying or screening agents that modulate nociception.</p> |
申请公布号 |
WO2004055054(A1) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003EP14403 |
申请日期 |
2003.12.17 |
申请人 |
NOVARTIS AG;NOVARTIS PHARMA GMBH;THE SCRIPPS RESEARCH INSTITUTE;BEVAN, STUART;PATAPOUTIAN, ARDEM;STORY, GINA, M. |
发明人 |
BEVAN, STUART;PATAPOUTIAN, ARDEM;STORY, GINA, M. |
分类号 |
C07K14/705;G01N33/50;(IPC1-7):C07K14/705;G01N33/68 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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