| 发明名称 |
MODULATION OF MATRIX METALLOPROTEINASE (MMP) ACTIVITY WITH ALDOSTERONE BLOCKER(S) |
| 摘要 |
The present invention is directed to a method for preventing an increase in matrix metalloproteinase (MMP) activity or reducing MMP activity in a subject in need thereof by administering to the subject a therapeutically effective amount of a selective aldosterone blocker. More particularly, the present invention is directed to attenuating or preventing an increase in MMP activity comprising administering eplerenone, or derivatives thereof. |
| 申请公布号 |
WO2004017906(A3) |
申请公布日期 |
2004.07.01 |
| 申请号 |
WO2003US26251 |
申请日期 |
2003.08.22 |
| 申请人 |
PHARMACIA CORPORATION;RUDOLPH, AMY, E.;MCMAHON, ELLEN, G. |
发明人 |
RUDOLPH, AMY, E.;MCMAHON, ELLEN, G. |
| 分类号 |
A61K45/00;A61K31/00;A61K31/56;A61K31/585;A61P3/10;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P13/12;A61P21/00;A61P25/00;A61P43/00 |
主分类号 |
A61K45/00 |
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