发明名称 |
MODIFYING THE DNA RECOMBINATION POTENTIAL IN EUKARYOTES |
摘要 |
The present invention provides methods of modifying in vivo mutagenesis or homeologous recombination in a eukaryote. The method of modifying in vivo mutagenesis involves transforming a eukaryote with a nucleotide sequence capable of expressing a wild-type prokaryotic MutS, MutL, MutH, MutU, NLS-MutS, NLS-MutL, NLS-MutH, NLS-MutU protein, or a combination thereof, and expressing the protein. A method of modifying recombination between homeologous chromosomes in an allopolyploid eukaryotic organism comprising, expressing a nucleotide sequence encoding prokaryotic NLS-MutS in combination with one or more than one of NLS-MutL, NLS-MutH, NLS-MutU, within a germ cell of the allopolyploid eukaryotic organism is also dislcosed. |
申请公布号 |
WO03104451(A3) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003CA00821 |
申请日期 |
2003.06.06 |
申请人 |
HER MAJESTY THE QUEEN IN RIGHT OF CANADA AS REPRES;ROZWADOWSKI, KEVIN, L.;LYDIATE, DEREK, J. |
发明人 |
ROZWADOWSKI, KEVIN, L.;LYDIATE, DEREK, J. |
分类号 |
A01H1/02;C12N15/10;C12N15/82 |
主分类号 |
A01H1/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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