发明名称 |
CYANAMIDES USEFUL AS REVERSIBLE INHIBITORS OF CYSTEINE PROTEASES |
摘要 |
Compounds according to the following formula (I): wherein the variables Q and Rl to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis. |
申请公布号 |
WO03086325(A3) |
申请公布日期 |
2004.07.01 |
申请号 |
WO2003US09852 |
申请日期 |
2003.04.01 |
申请人 |
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. |
发明人 |
LIU, WEIMIN;GILMORE, THOMAS, A.;HICKEY, EUGENE, RICHARD;NEMOTO, PETER, ALLEN;SPERO, DENICE, M. |
分类号 |
C07D295/18;A61K31/472;A61K31/5375;A61P9/10;A61P11/06;A61P15/00;A61P19/10;A61P25/00;A61P25/28;A61P29/00;A61P37/02;A61P43/00;C07C261/04;C07D217/06;C07D295/185 |
主分类号 |
C07D295/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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