发明名称 |
Pharmaceutical composition having reduced tendency for drug crystallization. |
摘要 |
Pharmaceutical compositions suitable for oral administration comprising paclitaxel, a solvent, a surfactant, a substituted cellulosic polymer, and optionally but preferably a P-glycoprotein inhibitor. The composition may further comprise a diglyceride or mixture of diglyceride and monoglyceride. The composition generates a supersaturated paclitaxel microemulsion upon contact with water resulting in improved oral bioavailability of paclitaxel. |
申请公布号 |
ZA200305086(B) |
申请公布日期 |
2004.06.30 |
申请号 |
ZA20030005086 |
申请日期 |
2003.06.30 |
申请人 |
PHARMACIA CORPORATION |
发明人 |
PING GAO;MICHAEL J HAGEMAN;WALTER MOROZOWICH;ROBERT J DALGA;KEVIN J STEFANSKI;TIEHUA HUANG;AZIZ KARIM;FRED HASSAN;JAMES C. FORBES |
分类号 |
A61K9/48;A61K31/00;A61K31/122;A61K31/138;A61K31/277;A61K31/337;A61K31/352;A61K31/365;A61K31/415;A61K31/42;A61K31/444;A61K31/49;A61K31/50;A61K31/52;A61K31/5415;A61K38/00;A61K45/00;A61K47/10;A61K47/14;A61K47/16;A61K47/22;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61P35/00;A61P43/00 |
主分类号 |
A61K9/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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