发明名称 |
Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues |
摘要 |
Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides. The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be therapeutically useful as antiviral and anticancer agents and may have other therapeutic or diagnostic uses. A method for making the hydrogen-phosphonodithioates is provided as well as a method for converting same to an activated intermediate for substitution on the phosphorus atom.
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申请公布号 |
US6756496(B1) |
申请公布日期 |
2004.06.29 |
申请号 |
US19970972998 |
申请日期 |
1997.11.19 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
FROEHLER BRIAN C.;BUHR CHRIS A. |
分类号 |
C07H19/04;C07H19/10;C07H19/20;(IPC1-7):C07H19/04 |
主分类号 |
C07H19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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