ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULES (ELAMS) AND MOLECULES INVOLVED IN LEUKOCYTE ADHESION (MILAS)

摘要

DNA sequences encoding endothelial calf-leukocyte adhesion molecules ELAMs, methods for producing such molecules, and ELAMs (including the specific molecules ELAM1 and VLAM1 and Ib) essentially free of normally associated animal proteins are disclosed. Antibodies to ELAMs are also disclosed. DNA sequences encodin g molecules involved in leukocyte adhesion (MILAs), method for producing such molecules and MILAs (including the specif ic molecule, CDX) essentially free of normally associated animal proteins are also disclosed. Antibody preparations which a re reactive for MILAs are also disclosed. Methods for identifying molecules which inhibit binding of leukocytes to endothelial cells, methods for inhibiting leukocyte binding to endothelial cells; and methods for detecting acute inflammation arty disclosed.