NOVEL USE OF SUBSTITUTED AMINOMETHYL CHROMANS FOR THE TREATMENT OF MOVEMENT DISORDERS AND OF ADVERSE EFFECTS INDUCED BY DRUGS ADMINISTERED TO TREAT EXTRAPYRAMIDAL MOVEMENT DISORDERS.

摘要

Substituted aminomethyl chromans, one of their optical isomers or pharmaceutically acceptable salts, used for the manufacture of a medicament for the treatment of adverse effects of anti-Parkinsonian drugs in extrapyramidal movement disorders and/or for the manufacture of a medicament for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics. A preferred compound is (-)-(R)-2 -{4-[[3, 4-dihydro-2H -benzopyran-2-yl) -methyl!amino!butyl} -1, 2-benzoisothiazol-3 -(2H)-on-1, 1-dioxide or a physiologically acceptable salt thereof.