发明名称 |
Variants of human ciliary neurotrophic factor (hCNTF) |
摘要 |
The variants of human ciliary neutrophic factor (hCNTF) according to the present invention are characterized by substitution of phenylalanine 152 and/or lysine 155 with alanine. These variants have biological properties that render them important as the active principles of drugs for the treatment of diseases and pathologies involving the nervous system or other pathologies involving cells responding to the CNTF. FIG. 2 shows the results of simulation of haptoglobin secretion from HepG2 cells by CNTF and the variants described in the invention.
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申请公布号 |
US6756357(B1) |
申请公布日期 |
2004.06.29 |
申请号 |
US19990214718 |
申请日期 |
1999.07.06 |
申请人 |
ISTITUTO DI RICHERCHE DI BIOLOGIA MOLECOLARE DI ANGELETTI S.P.A. |
发明人 |
LAUFER RALPH;DI MARCO ANNALISE |
分类号 |
C07K14/52;A61K38/00;A61P25/00;C07K14/475;C12N15/09;(IPC1-7):C07K14/475;A61K38/18 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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