发明名称 |
Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R, 4R)-4-hydroxy-6-oxo-tetrahydropyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide. |
摘要 |
An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process. |
申请公布号 |
ZA200304684(B) |
申请公布日期 |
2004.06.28 |
申请号 |
ZA20030004684 |
申请日期 |
2003.06.17 |
申请人 |
WARNER-LAMBERT COMPANY LLC. |
发明人 |
DONALD EUGENE BUTLER;JADE DOUGLAS NELSON;TIMOTHY LEE STUK;RANDALL LEE DEJONG;MICHAEL GERARD PAMMENT |
分类号 |
A61K31/4025;C07B61/00;C07D207/34;C07D295/18;C07D295/185;C07D405/06;C07D413/04 |
主分类号 |
A61K31/4025 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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