Pure N-(2-amino-4,6-dihalo-pyrimidin-6-yl)-formamide production, for use as intermediate for nucleotide antiviral agents, from corresponding diamine, formic acid and acetic anhydride

摘要

Production of N-(2-amino-4,6-dihalo-pyrimidin-6-yl)-formamides (I) involves reacting a 2,5-diamino-4,6-dihalo-pyrimidine (II) with formic acid in presence of acetic anhydride. Production of N-(2-amino-4,6-dihalo-pyrimidin-6-yl)-formamides of formula (I) involves reacting a 2,5-diamino-4,6-dihalo-pyrimidine of formula (II) (or its salt) with formic acid in presence of acetic anhydride. X = halo, preferably Cl.