| 摘要 |
A compound of formula (I") where; m is 0, 1, 2 or 3 ; each Rl independently represents halogen, cyano, nitro, carboxyl, hydroxyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, -NR9R10, C3-C6 cycloalkylamino, C1-C6 alkylthio, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino, sulphonamido, C1-C6 alkylsulphonyl, -C (O) NR11R12, -NR13 C(O)-(NH)pR14, phenyl, or C1-C6 alkyl optionally substituted by carboxyl or C1-C6 alkoxycarbonyl ; p is 0 or 1; X represents an oxygen or sulphur atom or a CH2, CH (CH3),OCH2, CH2O,CH2NH, NH or carbonyl group and Y represents a nitrogen atom or a CH or C (OH) group, provided that when X represents an oxygen or sulphur atom or a CH2O, CH2NH or NH group, then Y represents a CH group; Z1 represents a bond or a group (CH2)q where q is 1 or 2; Z2 represents a bond or a group CH2, with the proviso that Z1 and Z2 do not both simultaneously represent a bond; Q represents an oxygen or sulphur atom or a group CH2 or NH; R2 represents a group n is 0, 1 or 2 ; each R3 independently represents a C1-C6 alkyl, C1-C6 alkoxycarbonyl, -CH2OH or carboxyl group; R4,R5, R6 and R each independently represent a hydrogen atom or a C1-C6 alkyl group, or R4,R5, R6 and R7 together represent a C1-C4 alkylene chain linking the two carbon atoms to which they are attached to form a 4-to 7-membered saturated carbocycle, or R5, R6 and R each represent a hydrogen atom and R4 and R8 together with the carbon atoms to which they are attached form a 5- to 6-membered saturated carbocycle; R8 represents a hydrogen atom, a C1-C6 alkyl group or is linked to R4 as defined above; R9 and R10 each independently represent a hydrogen atom or a C1-C6 alkyl group, or R9 and R10 together with the nitrogen atom to which they are attached form a 4- to 7membered saturated heterocycle; R11 and R12 each independently represent a hydrogen atom or a C1-C6 alkyl group optionally substituted by C1-C6 alkoxycarbonyl ; R represents a hydrogen atom or a C1-C6 alkyl group ; and R14 represents a hydrogen atom, or a C1-C6 alkyl group optionally substituted by carboxyl, C1-C6 alkoxy or 1-C6 alkoxycarbonyl; provided that when X is an oxygen atom or a group CH2, Y is CH, Z1 and Z2 each represent a group CH2 and Q is an oxygen atom, then R2 is other than an unsubstituted indolyl group; Use of a compound of formula (I") in the manufacture of a medicament for the treatment of human diseases or conditions in which modulation of chemokine receptor activity is beneficial for example, rheumatoid arthritis, chronic obstructive pulmonary disease, asthma, multiple sclerosis. |
