Transgenic animal models for diseases that are regulated by G-protein signalling

摘要

A transgenic rat containing in its genome a nucleotide sequence encoding a mutant Galpha subunit protein or overexpressed nomal Galpha subunit protein, which Galpha protein subunit is uncoupled from regulation by regulators of G-protein signaling (RGS) proteins, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the Galpha subunit protein in neural cells resulting in extended G-protein coupled receptor signaling mediated by the Galpha subunit protein.