发明名称 |
Compounds for intracellular delivery of therapeutic moieties to nerve cells |
摘要 |
The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
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申请公布号 |
US2004120891(A1) |
申请公布日期 |
2004.06.24 |
申请号 |
US20030655756 |
申请日期 |
2003.09.05 |
申请人 |
HILL CRAIG;KAHL STEPHEN B.;WEBB ROBERT R.;MCKEE CONSTANCE A. |
发明人 |
HILL CRAIG;KAHL STEPHEN B.;WEBB ROBERT R.;MCKEE CONSTANCE A. |
分类号 |
A61K47/48;(IPC1-7):A61K51/00;C12P19/14;A61K39/395;C07K14/52;C07K16/46 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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