Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive.

摘要

The present invention relates to a pharmaceutical composition comprising ethinylestradiol and inert carrier particles containing drospirenone on their surface, wherein drospirenone is present in the composition in an amount corresponding to a daily dosage of from about 2 mg to about 4 mg; ethinylestradiol is present in the composition in an amount corresponding to a daily dosage of from about 0.01 mg to about 0.05 mg; and at least 70% of said drospirenone is dissolved from said composition within 30 minutes, as determined by USP XXIII Paddle Method II using water at 37 DEG C as the dissolution media and 50 rpm as the stirring rate.