| 摘要 |
PROBLEM TO BE SOLVED: To develop and provide a medicine for improving the fibrosing of a tissue by decreasing the expressing amount of type I collagen gene in the tissue to reduce the accumulated amount of the collagen. SOLUTION: This 2-pyrone compound is expressed by formula (I) (wherein, R is methyl, ethyl or allyl; R' is methyl or ethyl). The type I collagen gene transcription inhibitor contains the 2-pyrone compound as an active ingredient. Since the type I collagen gene transcription inhibitor decreases the expressing amount of the type I collagen gene to reduce the accumulated amount of the collagen, it is used for improving the fibrosing of the tissue. The medicinal agent for improving the fibrosing of the tissue contains the 2-pyrone compound. The method for improving the fibrosing of the tissue has a process of administering the 2-pyrone compound of an effective amount to a mammalian animal capable of being diagnosed as fibrosis. COPYRIGHT: (C)2004,JPO
|
