发明名称 |
COMPOSITIONS AND METHODS FOR INHIBITING MALARIA PROTEASE FALCIPAIN-2 |
摘要 |
The invention provides peptides derived from ankyrin and erythrocyte protein 4.1 that selectively inhibit falcipain-2-mediated cleavage of human erythrocyte protein 4.1, erythrocyte membrane ankyrin, and hemoglobin. Antibodies that bind to the falcipain-2 inhibitor peptides also are provided. Methods for selecting agents which inhibit falcipain-2 mediated parasite exit from host cells and methods of treatment which involve the peptides, nucleic acids encoding the peptides, and antibodies also are provided. |
申请公布号 |
WO2004052914(A2) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003US38835 |
申请日期 |
2003.12.05 |
申请人 |
CARITAS ST. ELIZABETH'S MEDICAL;HANSPAL, MANJIT;CHISHTI, ATHAR, H. |
发明人 |
HANSPAL, MANJIT;CHISHTI, ATHAR, H. |
分类号 |
A61K38/00;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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