发明名称 |
Hepatitis C virus assays |
摘要 |
The present invention includes an assay useful for identifying inhibitors of Hepatitis C virus (HCV) activity. Particularly, the present invention is directed to a dual HCV assay useful for high throughput screening that quantifies both the amount of HCV RNA replication inhibitory activity associated with a test compound and the amount of cytotoxicity associated with that test compound. The present invention also includes compounds discovered using this assay, compositions containing such compounds and methods of treating Hepatitis C by the administration of such compounds. The present invention also includes reporter assays using enzymes associated with HCV RNA replication, as well as a cell line having ATTC Accession No. PTA-4583. |
申请公布号 |
US2004121975(A1) |
申请公布日期 |
2004.06.24 |
申请号 |
US20030639150 |
申请日期 |
2003.08.12 |
申请人 |
GAO MIN;LEMM JULIE A.;O'BOYLE DONALD R.;NOWER PETER;RIGAT KAREN;SUN JIN-HUA |
发明人 |
GAO MIN;LEMM JULIE A.;O'BOYLE DONALD R.;NOWER PETER;RIGAT KAREN;SUN JIN-HUA |
分类号 |
A61K31/00;A61K31/426;A61K38/20;A61K38/21;A61K45/06;C07D277/42;C07D417/04;C07D417/06;C07D417/12;C07D417/14;C07D513/04;G01N33/576;(IPC1-7):C12Q1/70;A61K48/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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