发明名称 |
METHOD FOR PREPARING 4-HYDROXYISOLEUCINE DIASTEREOISOMERS AND ENANTIOMERS AND DERIVATIVES THEREOF |
摘要 |
<p>The invention concerns a method for preparing 4-hydroxyisoleucine diastereoisomers and enantiomers and derivatives thereof of general formula (I), characterized in that it consists in reducing an isoxazole derivative of formula (II) in conditions directly resulting in the derivatives of formula (I), or in obtaining at least a lactone of structure (III) in racemic form(s), or a enantiomerically enriched mixture, followed by opening, in basic conditions, in an aprotic or protic solvent, the desired lactone(s) and, optionally, separating the desired form. The invention is useful for preparing in particular (2S, 3R, 4S)-4-hydroxyisoleucine.</p> |
申请公布号 |
WO2004052836(A1) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003FR03542 |
申请日期 |
2003.12.01 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE LOUIS PASTEUR;MIOSKOWSKI, CHARLES;WAGNER, ALAIN;DE LAMO MARIN, SANDRA;CATALA, CEDRIC;BECHT, JEAN-MICHEL |
发明人 |
MIOSKOWSKI, CHARLES;WAGNER, ALAIN;DE LAMO MARIN, SANDRA;CATALA, CEDRIC;BECHT, JEAN-MICHEL |
分类号 |
C07C227/32;C07C229/22;C07C239/18;C07D307/66;(IPC1-7):C07C229/22 |
主分类号 |
C07C227/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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