发明名称 |
Human-type anti-blood coagulation factor viii antibody |
摘要 |
The present invention provides a human antibody against blood coagulation factor VIII (hereinafter also referred to as "FVIII") and an antibody fragment that binds to human FVIII and specifically inhibits the coagulation activity of human FVIII. ScFv display phage libraries, prepared by using scFv DNAs constructed by random combinations of immunoglobulin VH chain genes and VL chain genes from lymphocytes from hemophilia A patients, is reacted with FVIII immobilized to a solid phase via anti-FVIII monoclonal antibody, and scFv clones capable of binding to FVIII are cloned to reveal VH and VL chains of FVIII-specific antibody.
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申请公布号 |
US2004120951(A1) |
申请公布日期 |
2004.06.24 |
申请号 |
US20030344514 |
申请日期 |
2003.02.12 |
申请人 |
NAKASHIMA TOSHIHIRO;YUGUCHI MASATO |
发明人 |
NAKASHIMA TOSHIHIRO;YUGUCHI MASATO |
分类号 |
A61K38/00;C07K7/06;C07K7/08;C07K14/755;C07K16/36;C12P21/08;G01N33/86;(IPC1-7):A61K39/395;C07H21/04;C07K16/18 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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