发明名称 |
Process for preparation of 4-n-substituted amino-2-aza-1-oxabicyclo[3.3.0] oct-2-ene-6-carboxylic acid esters and process for preparation of their intermediates |
摘要 |
4-N-substituted amino-2-aza-1-oxabicyclo[3.3.0]oct-2-ene-6-carboxylic acid esters are produced by adding a Brønsted acid to a mixture of a 2-azabicyclo[2.2.1]hept-5-en-3-one and an alcohol, thereby causing these components to react with each other to give a salt of cis-4-amino-2-cyclopentene-1-carboxylic acid ester, then allowing the salt of cis-4-amino-2-cyclopentene-1-carboxylic acid ester thus obtained to react with an amino-protecting group introducing compound in the presence of a base, thereby giving cis-4-N-substituted amino-2-cyclopentene-1-carboxylic acid ester, and then allowing this cis-4-N-substituted amino-2-cyclopentene-1-carboxylic acid ester to react with a hypohalogenite and an aldoxime.
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申请公布号 |
US2004121482(A1) |
申请公布日期 |
2004.06.24 |
申请号 |
US20030399047 |
申请日期 |
2003.04.18 |
申请人 |
FUKUMOTO TAKASHI;TORIHARA MASAHIRO;TAMAI YOSHIN |
发明人 |
FUKUMOTO TAKASHI;TORIHARA MASAHIRO;TAMAI YOSHIN |
分类号 |
C07C229/48;C07D261/20;(IPC1-7):G01N21/00 |
主分类号 |
C07C229/48 |
代理机构 |
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地址 |
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