发明名称 |
STABILIZED IMMUNOGENIC HBc CHIMER PARTICLES |
摘要 |
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles is disclosed. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more of the N-terminus, the immunogenic loop or the C-terminus of HBc. The enhanced stability of self-assembled particles is obtained by the presence of at least one heterologous cysteine residue near one or both of the amino-terminus and carboxy-terminus of the chimer molecule and the absence of the cysteine residues present in the native sequence at HBc positions 48 and 107. |
申请公布号 |
WO2004053091(A2) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003US39164 |
申请日期 |
2003.12.10 |
申请人 |
APOVIA, INC. |
发明人 |
LYONS, KATELYNNE;BIRKETT, ASHLEY, J.;HARON, JAY, A. |
分类号 |
C07K14/02 |
主分类号 |
C07K14/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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