发明名称 |
INDOLE, AZAINDOLE AND RELATED HETEROCYCLIC UREIDO AND THIOUREIDO PIPERAZINE DERIVATIVES |
摘要 |
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with ureido and thioureido piperazine derivatives of Formula (I). These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. The compounds of Formula (I) are Formula (I) wherein:Y is O or S;Z is Formula (II); Q is selected from the group consisting of Formula (A) and Formula (B); m is 2;A is NR<13>R<14>; and-W- is Formula (C). |
申请公布号 |
WO2004011425(A3) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003US22735 |
申请日期 |
2003.07.22 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
REGUEIRO-REN, ALICIA;XUE, QIUFEN, MAY;KADOW, JOHN, F.;TAYLOR, MALCOLM |
分类号 |
A61K31/405;A61K31/4745;A61K31/496;A61K31/5377;C07D;C07D209/14;C07D209/18;C07D413/04;C07D417/12;C07D471/02;C07D471/04 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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