| 摘要 |
1. A prolactin lowering drug comprising at least one bicyclic diterpene compound of the labdane or clerodane type in accordance with at least one of general formulae (III) or (IV): wherein R1 =H, C1-3 alkyl or C1-3 acyl; wherein the rings A and/or B in the case of general formulae (I) or (II) are optionally substituted in position 1, 2, 3, 4, 6, 7, 8 or 9 with at least one OX radical, with X=H, C1-3 alkyl or C1-3 acyl; wherein the rings A and/or B in the case of general formulae (III) or (IV) are optionally substituted in position 1, 2, 3, 4, 6, 7, or 8 with at least one OX radical, with X=H, C1-3 alkyl or C1-3 acyl; wherein optionally at least one carbon atom in position 17, 18, 19 and 20 is substituted with an OX radical, with X=H, C1-3 alkyl or C1-3 acyl; wherein optionally at least one CH3 group in position 17, 18, 19 and 20 is replaced by one COOH group; wherein optionally at least one of ring positions 1, 2, 3, 6, or 7 is a keto group; and wherein optionally at least one double bond is present in ring positions 1, 2, 3, 6, 7, 8, 8(17) of formulae (I) and (III); and wherein optionally at least one double bond is present in ring positions 1, 2, 3, 6, 7, 8, 8(17) of formula (I) and 1, 2, 3, 4(18), 6, 7, 8, 8(17) of formula (IV); with the exception of the following compounds: larixolacetate, 7alpha-hydroxymanool, (+) hardwickiic acid, crolechinic acid, and hautriwaic acid ent-15,16-epoxy-9alphaH-labda-13(16)14-dien-3beta,8alpha-diol and methyl ether 15,16-epoxy-8(17), 14,16-labdasodium-19-acid. 2. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 3. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 4. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 5. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 6. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 7. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 8. A prolactin lowering drug according to claim 1, comprising a compound having the following formula: 9. Use a compound according to claims 1-8 for preparing a prolactin lowering drug for treating premenstrual syndrome, mastodynia, or a disorder of the menstrual cycle, in particular oligomenorrhea or amenorrhea. 10. Cleroda-Y, 14-dien-13-ol, wherein Y=ring positions 1, 2, 6, 7 or 8(17). 11. Use cleroda-Y, 14-dien-13-ol, wherein Y=ring positions 1, 2, 6, 7 or 8(17) for preparing a prolactin lowering drug for treating premenstrual syndrome, mastodynia, or a disorder of the menstrual cycle, in particular oligomenorrhea or amenorrhea. 12. Cleroda-Y,Z, 14-trien-13-ol, wherein Y or Z=ring position 1, 3, or 1, 4(18) or 1, 6 or 1, 7 or 1, 8(17) or ring position 2, 4(18) or 2, 6 or 2,7 or 2, 8(17) or ring position 4(18), 6 or 4(18), 7 or 4(18), 8(17) or ring position 6, 8(17). 13. Use cleroda-Y,Z, 14-trien-13-ol, wherein Y or Z=ring position 1, 3, or 1, 4(18) or 1, 6 or 1, 7 or 1, 8(17) or ring position 2, 4(18) or 2, 6 or 2,7 or 2, 8(17) or ring position 4(18), 6 or 4(18), 7 or 4(18), 8(17) or ring position 6, 8(17) for preparing a prolactin lowering drug for treating premenstrual syndrome, mastodynia, or a disorder of the menstrual cycle, in particular oligomenorrhea or amenorrhea. 14. Use a compound selected from the group, comprising compounds having the following formulae: in particular (rotundifuran) (sclareol) and also (solidagenon) for preparing a prolactin lowering drug.
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