发明名称 |
MODULATION OF STEM CELL DIFFERENTIATION BY MODULATION OF CASPASE-3 ACTIVITY |
摘要 |
Methods of directing stem cell fate for therapeutic purposes through the deliberate manipulation of caspase-3 activity are provided. The use of modulators of caspase-3 activity to modulate stem cell differentiation is described including activators and/or effectors of caspase-3, which can be used to induce stem cell differentiation, and inhibitors of caspase-3, which can be used to inhibit differentiation and thereby promote or maintain proliferation of stem cells. Methods of screening for modulators of caspase-3 and the use of such compounds to modulate stem cell differentiation in vitro or in vivo are also provided as are therapeutic applications of the compounds. |
申请公布号 |
WO2004053144(A2) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003CA01911 |
申请日期 |
2003.12.10 |
申请人 |
OTTAWA HEALTH RESEARCH INSTITUTE;MEGENEY, LYNN |
发明人 |
MEGENEY, LYNN |
分类号 |
C12N5/077;C12N5/0793;C12Q1/37;G01N33/573 |
主分类号 |
C12N5/077 |
代理机构 |
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