发明名称 |
DOPAMINERGIC NEURONS DIFFERENTIATED FROM EMBRYONIC CELLS FOR TREATING NEURODEGENERATIVE DISEASES |
摘要 |
Disclosed herein are methods for generating dopaminergic neurons in vitro by inhibiting a pathway component of a TGF-beta signaling pathway and overexpressing one or more cell fate-inducing polypeptides in pluripotent cells, causing differentiation of the pluripotent cells into dopaminergic neurons. Also disclosed are methods for treating a neurodegenerative disease in a patient by generating dopaminergic neurons in vitro and transplanting them into the brain of the patient, such that the dopaminergic neurons are sufficient to reduce or eliminate the symptoms of the neurodegerative disease. |
申请公布号 |
WO2004053084(A2) |
申请公布日期 |
2004.06.24 |
申请号 |
WO2003US38919 |
申请日期 |
2003.12.09 |
申请人 |
THE MCLEAN HOSPITAL CORPORATION |
发明人 |
ISACSON, OLE;BJOERKLUND, LARS |
分类号 |
C12N5/02;C12N5/0793 |
主分类号 |
C12N5/02 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|