PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED TOGETHER WITH MONOTHIOGLYCEROL L-CYSTEIN OR THIOGLYCOLIC ACID

摘要

1. A pharmaceutical composition comprising: a) pemetrexed; b) at least one antioxidant selected from the group consisting of: iv) monothioglycerol, v) L-cysteine, and vi) thioglycolic acid; and c) a pharmaceutically acceptable excipient. 2. A pharmaceutical composition as claimed by Claim 1 wherein the composition is a liquid formulation suitable for parenteral administration. 3. A pharmaceutical composition as claimed by any one of Claims 1 and 2 wherein pemetrexed is the disodium salt. 4. A pharmaceutical composition as claimed by any one of Claims 1 to 3 wherein the antioxidant is monothioglycerol. 5. A pharmaceutical composition as claimed in any one of Claims 1 to 4 wherein the monothioglycerol concentration is from about 1 part per million to about milligrams per milliliter. 6. A pharmaceutical composition of Claim 5 wherein the monothioglycerol concentration is from about 1 mg/ml to about 6 mg/ml. 7. A pharmaceutical composition of Claim 6 wherein the monothioglycerol concentration is from about 1 mg/ml to about 2.5 mg/ml. 8. A pharmaceutical composition of Claim 4 wherein the monothioglycerol concentration is from about 0.5 mg/ml to about 3 mg/ml. 9. A pharmaceutical composition as claimed by any one of Claims 1 to 3 wherein the antioxidant is L-cysteine. 10. A pharmaceutical composition of Claim 9 wherein the L-cysteine concentration is from about 1 part per million to about 8 mg/ml. 11. A pharmaceutical composition of Claim 10 wherein the L-cysteine concentration is from about 1 mg/ml to about 6 mg/ml. 12. A pharmaceutical composition of Claims 1 to 3 wherein the antioxidant is thioglycolic acid. 13. A pharmaceutical composition of Claim 12 wherein the thioglycolic acid concentration is from about 1 part per million to about 8 mg/ml. 14. A pharmaceutical composition of Claim 13 wherein the thioglycolic acid concentration is from about 0.1 mg/ml to about 6 mg/ml. 15. A pharmaceutical composition of Claim 4 wherein the monothioglycerol concentration is from about 0.1 mg/ml to about mg/ml. 16. A pharmaceutical composition of Claim 15 wherein the monothioglycerol concentration is from about 0.1 mg/ml to about 6 mg/ml. 17. A pharmaceutical composition of Claim 9 wherein the L-cysteine is from about 0.1 mg/ml to about 10 mg/ml. 18. A pharmaceutical composition of Claim 17 wherein the L-cysteine is from about 0.1 mg/ml to about 6 mg/ml. 19. A pharmaceutical composition of Claim 12 wherein the thioglycolic acid is from about 0.1 mg/ml to about 10 mg/ml. 20. A pharmaceutical composition of Claim 19 wherein the thioglycolic acid is from about 0.1 mg/ml to about 6 mg/ml.