BIOINFORMATICS ANALYSIS OF CELLULAR EFFECTS OF ARTIFICIAL TRANSCRIPTION FACTORS

摘要

Disclosed is a method of evaluating a plurality of cellular genes. The method includes: providing a plurality of cells, each cell containing a nucleic acid encoding a different artificial, chimeric transcription factor; expressing the respective nucleic acids in the cells of the plurality; evaluating expression of a plurality of genes in each cell of the plurality to provide expression information; and identifying, from the expression information, a set of two or more genes whose expression is co-regulated among the cells of the plurality.