| 摘要 |
1. A topical composition comprising at least about 5.0 % (w/v) ascorbic acid, water; non-toxic zinc salt and tyrosine compound, wherein the composition has a pH of more than 3.5. 2. The composition of claim 1, wherein the composition has a pH of about 3.6 to about 4.2. 3. The composition of claim 2, wherein the composition has a pH of about 3.7 to about 4.0. 4. The composition of claim 1 further comprising an anti-inflammatory compound. 5. The composition of claim 4, wherein the anti-inflammatory compound includes sulfur-containing anti-inflammatory compound. 6. The composition of claim 5, wherein the sulfur-containing anti-inflammatory compound is selected from the group consisting of cystine, cysteine, N-acetyl cysteine, glutathione, cysteamine, S-methylcysteine, methionine and mixtures thereof. 7. The composition of claim 4, wherein the anti-inflammatory compound includes aminosugar. 8. The composition of claim 7, wherein the aminosugar includes glucosamine, mannosamine, N-acetylmannosamine, galactosamine, glucosamine-6-phosphate, N-acetylglucosamine, N-acetylmannosamine, N-acetylgalactosamine and mixtures thereof. 9. The composition of claim 1 comprising about 15 % (w/v) to about 25 % (w/v) ascorbic acid. 10. The composition of claim 1, wherein the water is selected from the group consisting of distilled water, deionized water, distilled deionized water and mixtures thereof. 11. The composition of claim 1, wherein the composition comprises about 0.5 to about 5 % (w/v) of the non-toxic zinc salt. 12. The composition of claim 1, wherein the non-toxic zinc salt is zinc sulfate. 13. The composition of claim 1, wherein the tyrosine compound is selected from the group consisting of tyrosine, N-acetyltyrosine, tyrosine ethyl ester hydrochloride, tyrosine phosphate and mixtures thereof. 14. The composition of claim 1 comprising about 1 to about 10 % (w/v) tyrosine compound. 15. The composition of claim 1 further comprising cosmetically acceptable carrier. 16. The composition of claim 1, wherein the cosmetically acceptable carrier includes glycerol, propyleneglycol, sorbitol, hydroxypropylcellulose or a mixture thereof. 17. The composition of claim 1 wherein the cosmetically acceptable carrier includes alkyleneglycol, hydroxyalkylcellulose or a mixture thereof. 18. A topical composition comprising an aqueous solution including at least about 5.0 % (w/v) ascorbic acid, wherein about 10 to about 50 % of the ascorbic acid is prepared by dissolving at least about 20 % (w/v) ascorbic acid in water at 60 to 90 degree C. 19. The composition of claim 18, wherein the aqueous solution has a pH of more than about 3.5. 20. The composition of claim 18 further comprising non-toxic zinc salt. 21. The composition of claim 18 further comprising a stimulant of protein synthesis. 22. The composition of claim 18, wherein the stimulant of protein synthesis is a tyrosine compound. 23. The composition of claim 18 further comprising a precursor of melanin synthesis. 24. The composition of claim 18 comprising about 15 to about 25 % (w/v) ascorbic acid. 25. A method of treating damage to skin comprising a step of applying a topical composition to the skin, wherein the topical composition comprises at least about 5.0 % (w/v) ascorbic acid, water, non-toxic zinc salt and tyrosine compound, and the composition has a pH of more than 3.5. 26. The method of claim 25 comprising applying the topical composition to the skin once or twice daily. 27. The method of claim 25 wherein the topical composition is an aqueous solution, a lotion, an ointment, a cream, or a gel. 28. A method of treating damage to skin comprising a step of applying a topical composition to the skin, the topical composition comprising an aqueous solution including at least about 5.0 % (w/v) ascorbic acid, wherein about 10 to about 50 % of the ascorbic acid is prepared by dissolving at least about 20 % (w/v) ascorbic acid in water at 60 to 90 degree C. 29. A method of protecting skin against damage due to exposure to radiation or chemicals comprising a step of applying a topical composition to the skin, wherein the topical composition comprises at least about 5.0 % (w/v) ascorbic acid, water, non-toxic zinc salt; and tyrosine compound; and the composition has a pH of more than 3.5. 30. A method of protecting skin against damage due to exposure to radiation or chemicals comprising a step of applying a topical composition to the skin, the topical composition comprising an aqueous solution including at least about 5.0 % (w/v) ascorbic acid, wherein about 10 to about 50 % of the ascorbic acid is prepared by dissolving at least about 20 % (w/v) ascorbic acid in water at 60 to90 degree C. 31. The method of claim 30, wherein the radiation includes ultraviolet radiation.
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