Compounds, compositions and methods are provided for modulating the expression of PPAR-alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding PPAR-alpha. Methods of using these compounds for modulation of PPAR-alpha expression and for diagnosis and treatment of disease associated with expression of PPAR-alpha are provided.
申请公布号
WO2004052306(A2)
申请公布日期
2004.06.24
申请号
WO2003US39429
申请日期
2003.12.11
申请人
ISIS PHARMACEUTICALS INC.;MCKAY, ROBERT;DOBIE, KENNETH, W.