发明名称 |
A METHOD FOR PREPARING LIPOSOME FORMULATIONS WITH A PREDEFINED RELEASE PROFILE |
摘要 |
The present invention provides a novel tool for designing a release profile of an active agent from a liposome in to which it is loaded. According to the invention, a method is provided for preparing a liposomal formulation for delivery of an active agent to a target, the release of said active agent from the liposome being designed to have a release profile in which the release is sustained for a time period to achieve an optimal effect of the active agent at said target, the method comprising preparing a liposomal formulation, wherein the liposome is loaded with said active agent and with a selected counter ion, the counter ion and the active agent interacting together to aggregate and/or to form a precipitate within the liposome, the counter ion being selected such that the release of the active agent from the liposome has said release profile. |
申请公布号 |
EP1429726(A2) |
申请公布日期 |
2004.06.23 |
申请号 |
EP20020801474 |
申请日期 |
2002.09.09 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM |
发明人 |
BARENHOLZ, YECHEZKEL;WASSERMAN, VERONICA |
分类号 |
A61K9/127;A61K47/00;A61K47/02;A61K47/12;A61K47/36;(IPC1-7):A61K9/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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