RECEPTOR ANTAGONIST

摘要

The present invention provides an alpha 2c-adrenoceptor antagonist comprising, as an active ingredient, a condensed-ring-pyrimidine derivative represented by general formula (I) below or a pharmaceutically acceptable salt thereof useful for treating and/or preventing various diseases induced by hyperactivity of alpha 2c-adrenoceptor (for example, Parkinson's disease, L-DOPA-induced dyskinesia, tardive dyskinesia and depression) and the like. <CHEM> äwherein p represents an integer of 1 to 3; R<1> represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R<2> represents -N(-R<4>)(-R<5>) (wherein R<4> and R<5> are the same or different, and each represents a hydrogen atom, substituted or unsubstituted aralkyl, or the like, or R<4> and R<5> form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the like; and -Q- represents -N=C(-R<7>)- Äwherein R<7> represents -N(-R<9>) (-R<10>) (wherein R<9> and R<10> are the same or different, and each represents substituted or unsubstituted aralkyl, or the like, or R<9> and R<10> form a substituted or unsubstituted heterocyclic group together with the adjacent nitrogen atom) or the likeÜ or the likeü