| 摘要 |
The invention provides a human PDE4C which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases (in particular angina and coronary heart disease), hematological diseases, inflammation, cancer, gastroenterological diseases and respiratory disease. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases (in particular angina and coronary heart disease), hematological diseases, inflammation, cancer, gastroenterological diseases and respiratory disease. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE4C as well as pharmaceutical compositions comprising such compounds. |
