发明名称 |
ARPE-19 AS A PLATFORM CELL LINE FOR ENCAPSULATED CELL-BASED DELIVERY |
摘要 |
ARPE-19 cells were evaluated as a platform cell line for encapsulated and un-encapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under stringent conditions, such as in central nervous system or intra-ocular environment); can be genetically modified to secrete the protein of choice; has a long life span; is of human origin; has good in vivo device viability; delivers efficacious quantity of growth factor; triggers no or low level host immune reaction, and is non-tumorigenic. |
申请公布号 |
EP1171573(B1) |
申请公布日期 |
2004.06.23 |
申请号 |
EP20000923144 |
申请日期 |
2000.04.06 |
申请人 |
NEUROTECH S.A. |
发明人 |
TAO, WENG;REIN, DAVID, H.;DEAN, BRENDA, J.;STABILA, PAUL, F.;GODDARD, MOSES, B., I. |
分类号 |
C12N15/09;A61K9/00;A61K9/48;A61K9/50;A61K35/12;A61K35/44;A61K38/18;A61K48/00;A61P3/00;A61P9/00;A61P11/06;A61P25/16;A61P25/28;A61P27/02;A61P35/00;C12N5/071;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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