Protofibril specific antibodies and uses thereof

摘要

The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Abeta 42/40 protofibril comprising N-terminal truncated Abeta forms and (ii) Abeta 42/40 Arc protofibril comprising N-terminal truncated Abeta forms and (b) has no or little cross-reactivity to Abeta 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.