| 发明名称 |
5-[(4-METHYL-1-PIPERAZINYLSULFONYL)-2-SUBSTITUTED BENZAMIDO] -1-METHYL-3-PROPYL-1H-PYRAZOLE-5- CARBOXAMIDES, THEIR PREPARATION AND A PROCESS FOR THE PREPARATION OF SILDENAFIL THEREFROM |
| 摘要 |
A process is provided for the preparation of a compound of formulae (IA) (sidenafil/ ViagraTm TM ) and (IB) <CHEM> comprising reacting a compound of formula (IIA) and (IIB) respectively in the presence of <->OR, wherein R in the case of formation of compound (IA) is CH2CH3 and R in the case of formation of compound (IB) is CH2CH2CH3, where X is a leaving group: <CHEM> |
| 申请公布号 |
IL132273(A) |
申请公布日期 |
2004.06.20 |
| 申请号 |
IL19990132273 |
申请日期 |
1999.10.07 |
| 申请人 |
PFIZER IRELAND PHARMACEUTICALS |
发明人 |
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| 分类号 |
C07D295/22;A61K31/519;A61P15/10;C07D231/40;C07D231/54;C07D295/26;C07D401/02;C07D401/06;C07D487/00;C07D487/04;(IPC1-7):C07D487/04;C07D403/12 |
主分类号 |
C07D295/22 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
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