摘要 |
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds identified according to the methods described herein can be used to treat disorders characterized by excessive apoptosis, e.g., a neurological disorder, or insufficient apoptosis, e.g., cancer. |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;THE UNIVERSITY OF CHICAGO;KUFE, DONALD, W.;KADDURAH-DAOUK, RIMA;WEICHSELBAUM, RALPH, R. |
发明人 |
KUFE, DONALD, W.;KADDURAH-DAOUK, RIMA;WEICHSELBAUM, RALPH, R. |