发明名称 |
SINGLE POT CONVERSION OF ARTEMISININ INTO ARTEETHER |
摘要 |
The present invention provides a method for the preparation of arteether fro m artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride i n ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.
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申请公布号 |
CA2507078(A1) |
申请公布日期 |
2004.06.17 |
申请号 |
CA20022507078 |
申请日期 |
2002.11.29 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH |
发明人 |
BHAKUNI, RAGENDRA SINGH;TEWARI, AMIT;KHANUJA, SUMAN PREET SINGH;SINGH, TARUN |
分类号 |
C07D307/92;C07D493/18;C07D493/22;(IPC1-7):C07D493/22 |
主分类号 |
C07D307/92 |
代理机构 |
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地址 |
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