| 摘要 |
The present invention provides a medical device, preferably a contact lens, which comprises an antimicrobial LbL coating containing one or more antimicrobial peptides. The antimicrobial coating of the invention can impar t to the medical an increased surface hydrophilicity and a relatively high antimicrobial activity coupled with low cytotoxicity. The antimicrobial coating of the invention has a minimal adverse effects on the desirable bulk properties of a contact lens, such as oxygen permeability, ion permeability, and optical properties. An antimicrobial coating of the present invention ma y find particular use in extended-wear contact lenses. In addition, the invention provides a method for making a medical device, preferably a contac t lens, having an antimicrobial LbL coating thereon.
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