NOVEL ADAPTOR PROTEIN BINDING TO MAMMALIAN TOLL-LIKE RECEPTOR 3 AND GENE THEREOF

摘要

It is intended to provide a novel adaptor protein efficacious in preventing and treating viral infections such as hepatitis B and hepatitis C and treati ng tumor, etc. which controls the production of I-type interferon and binds to mammalian Toll-like receptor 3, and its gene. A novel adaptor protein TICAM- 1 comprising an amino acid sequence represented by SEQ ID NO:2 or 4, binding specifically to mammalian Toll-like receptor 3 and inducing the production o f I-type interferon. A mutant of the above adaptor protein TICAM-1 has the sam e properties, so long as it carries a TIR domain (an amino acid sequences ranging from the 394-position to the 532-position in the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequences ranging from the 396- position to the 534-position in the amino acid sequence represented by SEQ I D NO:4). A gene encoding the above adaptor protein TICAM-1.