COMPOUNDS RESISTANT TO METABOLIC DEACTIVATION AND METHODS OFUSE

摘要

Therapeutic compounds having increased resistance to deamination and inactivation by metabolic enzymes are provided. The compounds include nucleotide analogs and nucleotide analogs, derivatized with aminal and/or thioaminal groups to prevent deamination of free amine. The compounds can be used in a variety of treatments, including treatment of neoplastic disorders , infections from fungal or fungal like organisms, and infections from parasit es.