| 摘要 |
PROBLEM TO BE SOLVED: To obtain a therapeutic agent for retinal diseases, containing PACAP(Pituitary Adenylate Cyclase Activating Polypeptide) derivative. SOLUTION: This therapeutic agent for retinal diseases contains a peptide represented by the formula (I) His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Arg-Gln-X<SB>1</SB>-Ala-Val-Arg-Arg-Tyr-Leu-Ala-Ala-Val-Leu-X<SB>2</SB>-R (I) or its pharmaceutically permissible salt (X<SB>1</SB>is Leu, Met or Nle; X<SB>2</SB>is Gly, Gly-Arg, Gly-Lys, Gly-Lys-Arg, Gly-Arg-Arg or a chemical bond; R is NH<SB>2</SB>or OH; when X<SB>2</SB>is the chemical bond, X<SB>1</SB>is Met or Nle and when X<SB>2</SB>is except the chemical bond, X<SB>1</SB>is Leu). COPYRIGHT: (C)2004,JPO
|
