| 摘要 |
The invention relates to indole derivatives of formula (I) or (II) for use as inflammation modulators, especially having an inhibitory effect on protein kinases. Formula (I), wherein n=0 or 1, R<1>=R<2>=3-indole, R<3>=COOH- or a ketone, X=O or NH; with the proviso that if n=0, R<4>=OH and R<5>=3-indole; and if n=1, R<4 >together with R<5 >represents an indole ring system condensed to the structure in the 2,3 position and X=NH. Formula (II), wherein R<1>=R<2>=3-indole, X=O, CH2 or a carbonyl group; X=O, a carbonyl group NH or >C=N(R')2 with R'=CH3 or C2H5. The novel indole derivatives isolated from Melassezia are especially useful as substances for producing a medicament for the treatment of inflammatory or proliferative diseases, especially of the skin, but also of other organ systems.
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