SINGLE POT CONVERSION OF ARTEMISININ INTO ARTEETHER
摘要
<p>The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.</p>
申请公布号
WO2004050662(A1)
申请公布日期
2004.06.17
申请号
WO2002IB05074
申请日期
2002.11.29
申请人
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;BHAKUNI, RAGENDRA, SINGH;TEWARI, AMIT;SINGH, TARUN;KHANUJA, SUMAN, PREET, SINGH