发明名称 |
Affinity small molecules for the EPO receptor |
摘要 |
Compounds are provided that complex with the modulating domain of erythropoietin receptor (EPO-R) for use with EPO-R to determine the presence of EPO-R, the ability of other molecules to bind to the modulating domain in competitive assays and to induce a signal by EPO-R into a cell when bound by the subject compounds in a physiological environment. The compounds are characterized by having a six-membered heterocyclic ring comprising at least one nitrogen atom and include substituted triazolopyrimidine, pyridazinone, pyridine and piperidine.
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申请公布号 |
US2004116346(A1) |
申请公布日期 |
2004.06.17 |
申请号 |
US20030612885 |
申请日期 |
2003.07.03 |
申请人 |
OLSSON LENNART;NARANDA TATJANA |
发明人 |
OLSSON LENNART;NARANDA TATJANA |
分类号 |
A61K31/519;A61K38/17;A61K45/06;C07D487/04;C07K14/71;G01N33/566;G01N33/74;(IPC1-7):A61K38/17;A61K31/501;A61K31/474;A61K31/44 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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地址 |
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