POLYVALENT, PRIMARY HIV-1 GLYCOPROTEIN DNA VACCINES AND VACCINATION METHODS
摘要
<p>Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more differe nt HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protei n. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided.</p>
申请公布号
CA2505583(A1)
申请公布日期
2004.06.17
申请号
CA20032505583
申请日期
2003.12.03
申请人
UNIVERSITY OF MASSACHUSETTS;ADVANCED BIOSCIENCE LABORATORIES, INC.
发明人
KEEN, TIM;NAIR, BALACHANDRAN C.;LU, SHAN;MARKHAM, PHILLIP;WANG, SHIXIA;PAL, RANAJIT;KALYANARAMAN, V. S.;WHITNEY, STEPHEN CHARLES