发明名称 |
COMPOUNDS RESISTANT TO METABOLIC DEACTIVATION AND METHODS OF USE |
摘要 |
Therapeutic compounds having increased resistance to deamination and inactivation by metabolic enzymes are provided. The compounds include nucleotide analogs and nucleotide analogs, derivatized with aminal and/or thioaminal groups to prevent deamination of free amine. The compounds can be used in a variety of treatments, including treatment of neoplastic disorders, infections from fungal or fungal like organisms, and infections from parasites. |
申请公布号 |
WO2004050678(A2) |
申请公布日期 |
2004.06.17 |
申请号 |
WO2003US38638 |
申请日期 |
2003.12.03 |
申请人 |
BAYLOR UNIVERSITY;KANE, ROBERT, RONALD;CHANG, HU-MIN |
发明人 |
KANE, ROBERT, RONALD;CHANG, HU-MIN |
分类号 |
A61K31/70;A61P35/02;C07H19/04 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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